Cold-adapted influenza viruses as a promising platform for viral-vector vaccines
نویسندگان
چکیده
منابع مشابه
Viral vector-based influenza vaccines
Antigenic drift of seasonal influenza viruses and the occasional introduction of influenza viruses of novel subtypes into the human population complicate the timely production of effective vaccines that antigenically match the virus strains that cause epidemic or pandemic outbreaks. The development of game-changing vaccines that induce broadly protective immunity against a wide variety of influ...
متن کاملDevelopment and characterization of cold-adapted viruses for use as live virus vaccines.
Representative viruses from twelve RNA and two DNA virus genera have been successfully adapted to growth at sub-optimal temperature (cold-adapted). In almost every case, there was a correlation between acquisition of the cold-adaptation phenotype and loss of virulence in the normal host whether animal or man. Overall, the best method of cold adaptation to develop a live virus vaccine line appea...
متن کاملRecombinant viruses as vaccines against viral diseases.
Vaccine approaches to infectious diseases are widely applied and appreciated. Amongst them, vectors based on recombinant viruses have shown great promise and play an important role in the development of new vaccines. Many viruses have been investigated for their ability to express proteins from foreign pathogens and induce specific immunological responses against these antigens in vivo. General...
متن کاملUse of live cold-adapted influenza A H1N1 and H3N2 virus vaccines in seropositive adults.
To investigate the immunogenicity and protective efficacy of cold-adapted influenza vaccine in individuals with underlying immunity to influenza A virus, we administered cold-adapted H1N1 and H3N2 vaccines to adults with prevaccination serum hemagglutination inhibition antibody titers of 1:16 or more and challenged them 1 month afterwards with homologous wild-type influenza A virus. Both cold-a...
متن کاملDevelopment of Cold-adapted Recombinant Live, Attenuated Influenza a Vaccines in the U.s.a. and U.s.s.r
Influenza remains a major public health problem in many countries. Periodic epidemics disrupt economic and social activities within entire communities, impose sudden large demands on available medical facilities, and can cause excess mortality, particularly in the elderly or those with certain chronic illnesses [5,7,21]. Vaccination can provide significant protection against infection and illne...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Expert Review of Vaccines
سال: 2016
ISSN: 1476-0584,1744-8395
DOI: 10.1080/14760584.2016.1208088